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1

Quantitative mass balance, tissue distribution, pharmacokinetics and biotransformation pathway of praliciguat, a clinical-stage sgc stimulator, after oral administration in rats

Banijamali, Ali, Carvalho, Andrew, Wakefield, James, Germano, Peter, Ribadeneira, Maria, Barden, Timothy, Zimmer, Daniel, Masferrer, Jaime, Profy, Albert, Currie, Mark, Milne, Todd, Germano, Peter

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2019

Language:

english

File:

PDF, 66 KB

english, 2019

2

Safety and effectiveness of BufferGel and 0.5% PRO2000 gel for the prevention of HIV infection in women

Abdool Karim, Salim S, Richardson, Barbra A, Ramjee, Gita, Hoffman, Irving F, Chirenje, Zvavahera M, Taha, Taha, Kapina, Muzala, Maslankowski, Lisa, Coletti, Anne, Profy, Albert, Moench, Thomas R, Piw

Journal:

Year:

2011

Language:

english

File:

PDF, 220 KB

english, 2011

3

PRO 2000, a broadly active anti-HIV sulfonated compound, inhibits viral entry by multiple mechanisms

Dana Huskens, Albert T Profy, Kurt Vermeire, Dominique Schols

Journal:

Year:

2010

Language:

english

File:

PDF, 130 KB

english, 2010

4

Principal Neutralizing Domain of the Human Immunodeficiency Virus Type 1 Envelope Protein

Kashi Javaherian, Alphonse J. Langlois, Charlene McDanal, Karen L. Ross, Lawrence I. Eckler, Cindy L. Jellis, Albert T. Profy, James R. Rusche, Dani P. Bolognesi, Scott D. Putney and Thomas J. Matthew

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 903 KB

english, 1989

5

PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity

Keller, Marla J, Guzman, Esmeralda, Hazrati, Ehsan, Kasowitz, Andrea, Cheshenko, Natalia, Wallenstein, Sylvan, Cole, Amy L, Cole, Alexander M, Profy, Albert T, Wira, Charles R, Hogarty, Kathleen, Hero

Journal:

Year:

2007

Language:

english

File:

PDF, 226 KB

english, 2007

6

The Topical Microbicide PRO 2000 Protects against Genital Herpes Infection in a Mouse Model

Nigel Bourne, David I. Bernstein, James Ireland, Andrew J. Sonderfan, Albert T. Profy and Lawrence R. Stanberry

Journal:

The Journal of Infectious Diseases

Year:

1999

Language:

english

File:

PDF, 658 KB

english, 1999

7

The Topical Microbicide PRO 2000 Protects against Genital Herpes Infection in a Mouse Model

Bourne, Nigel, Bernstein, David I., Ireland, James, Sonderfan, Andrew J., Profy, Albert T., Stanberry, Lawrence R.

Journal:

The Journal of Infectious Diseases

Year:

1999

Language:

english

File:

PDF, 55 KB

english, 1999

8

Immunoassay to measure staphylococcal protein A in the presence of murine immunoglobulins

Susan M. Knicker, Albert T. Profy

Journal:

Journal of Immunological Methods

Year:

1991

Language:

english

File:

PDF, 484 KB

english, 1991

9

FIRST-IN-HUMAN SINGLE-ASCENDING-DOSE STUDY OF IW-1973, A NEW SOLUBLE GUANYLATE CYCLASE STIMULATOR

Hanrahan, John, Profy, Albert T., Lavins, B. Joseph, Ruff, Dennis, Poirier, Gabrielle, Wakefield, James, Wilson, Phebe, Hall, Michael, Currie, Mark G.

Journal:

Journal of the American College of Cardiology

Year:

2016

Language:

english

File:

PDF, 370 KB

english, 2016

10

Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinicalâstage soluble guanylate cyclase stimulator in rats

Banijamali, Ali R., Carvalho, Andrew E., Wakefield, James D., Germano, Peter, Barden, Timothy C., Tobin, Jenny V., Zimmer, Daniel P., Masferrer, Jaime L., Profy, Albert T., Currie, Mark G., Todd Milne

Journal:

Pharmacology Research & Perspectives

Year:

2020

File:

PDF, 2.10 MB

2020

11

Effect of Praliciguat on Peak Rate of Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction

Udelson, James E., Lewis, Gregory D., Shah, Sanjiv J., Zile, Michael R., Redfield, Margaret M., Burnett, John, Parker, John, Seferovic, Jelena P., Wilson, Phebe, Mittleman, Robert S., Profy, Albert T.

Journal:

Year:

2020

File:

PDF, 467 KB

2020

12

Solution conformational preferences of immunogenic peptides derived from the principal neutralizing determinant of the HIV-1 envelope glycoprotein gp120

Chandrasekhar, K., Profy, Albert T., Dyson, H. Jane

Journal:

Year:

1991

Language:

english

File:

PDF, 1.23 MB

english, 1991

13

The Acceptability of an Investigational Vaginal Microbicide, PRO 2000 Gel, among Women in a Phase I Clinical Trial

Morrow, Kathleen, Rosen, Rochelle, Richter, Linda, Emans, Anne, Forbes, Anna, Day, Jennifer, Morar, Neetha, Maslankowski, Lisa, Profy, Albert T., Kelly, Cliff, Abdool Karim, Salim S., Mayer, Kenneth H

Journal:

Journal of Women's Health

Year:

2003

Language:

english

File:

PDF, 174 KB

english, 2003

14

Phase I safety study of 0.5% PRO 2000 vaginal Gel among HIV un-infected women in Pune, India

Joshi Smita, Dutta Soma, Bell Beverly, Profy Albert, Kuruc JoAnn, Gai Fang, Cianciola Missy, Soto-Torres Lydia, Panchanadikar Anjali, Risbud Arun, Mehendale Sanjay, Reynolds Steven J, the HIV Preventi

Journal:

AIDS Research and Therapy

Year:

2006

Language:

english

File:

PDF, 186 KB

english, 2006

15

Stereoselective aminoacylation of a dinucleoside monophosphate by the imidazolides ofDl-alanine and N-(tert-butoxycarbonyl)-Dl-alanine

Albert T. Profy, D. A. Usher

Journal:

Journal of Molecular Evolution

Year:

1984

Language:

english

File:

PDF, 1005 KB

english, 1984

16

The candidate sulfonated microbicide, PRO 2000, has potential multiple mechanisms of action against HIV-1

Dana Huskens, Kurt Vermeire, Albert T. Profy, Dominique Schols

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 1.01 MB

english, 2009

17

Major antigen-induced domain rearrangements in an antibody

Robyn L Stanfield, Midori Takimoto-Kamimura, James M Rini, Albert T Profy, Ian A Wilson

Journal:

Year:

1993

Language:

english

File:

PDF, 11.74 MB

english, 1993

18

PRO 2000 Gel Inhibits HIV and Herpes Simplex Virus Infection Following Vaginal Application: A Double‐Blind Placebo‐Controlled Trial

Keller, Marla J., Zerhouni‐Layachi, Bouchra, Cheshenko, Natalia, John, Minnie, Hogarty, Kathleen, Kasowitz, Andrea, Goldberg, Cindy L., Wallenstein, Sylvan, Profy, Albert T., Klotman, Mary E., Herold,

Journal:

The Journal of Infectious Diseases

Year:

2006

Language:

english

File:

PDF, 150 KB

english, 2006

19

Postcoital Bioavailability and Antiviral Activity of 0.5% PRO 2000 Gel: Implications for Future Microbicide Clinical Trials

Keller, Marla J., Mesquita, Pedro M. M., Torres, N. Merna, Cho, Sylvia, Shust, Gail, Madan, Rebecca P., Cohen, Hillel W., Petrie, Julie, Ford, Tara, Soto-Torres, Lydia, Profy, Albert T., Herold, Betsy

Journal:

Year:

2010

Language:

english

File:

PDF, 295 KB

english, 2010

20

ACIDFORM Inactivates Herpes Simplex Virus and Prevents Genital Herpes in a Mouse Model: Optimal Candidate for Microbicide Combinations

Tuyama, Ana C. G., Cheshenko, Natalia, Carlucci, Maria J., Li, Jin‐Hua, Goldberg, Cindy L., Waller, Donald P., Anderson, Robert A., Profy, Albert T., Klotman, Mary E., Keller, Marla J., Herold, Betsy

Journal:

The Journal of Infectious Diseases

Year:

2006

Language:

english

File:

PDF, 974 KB

english, 2006

21

[Progress in Nucleic Acid Research and Molecular Biology] Volume 35 || Complementary Use of Chemical Modification And Site-Directed Mutagenesis to Probe Structure-Activity Relationships in Enzymes

Profy, Albert T.

Year:

1988

Language:

english

File:

PDF, 1.51 MB

english, 1988

22

A Randomized, Placebo-Controlled, Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Soluble Guanylate Cyclase Stimulator Praliciguat in Healthy Subjects

Hanrahan, John P., Wakefield, James D., Wilson, Phebe J., Mihova, Marina, Chickering, Jennifer G., Ruff, Dennis, Hall, Michael, Milne, G. Todd, Currie, Mark G., Profy, Albert T.

Journal:

Clinical Pharmacology in Drug Development

Year:

2018

Language:

english

File:

PDF, 672 KB

english, 2018

23

Crystal Structure of a Human Immunodeficiency Virus Type 1 Neutralizing Antibody, 50.1, in Complex with Its V3 Loop Peptide Antigen

James M. Rini, Robyn L. Stanfield, Enrico A. Stura, Paul A. Salinas, Albert T. Profy and Ian A. Wilson

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 1.35 MB

english, 1993

24

Stereoselective aminoacylation of polyribonucleotides

Profy, Albert T., Usher, D. A.

Journal:

Journal of the American Chemical Society

Year:

1984

Language:

english

File:

PDF, 313 KB

english, 1984

25

Safety and Acceptability of Penile Application of 2 Candidate Topical Microbicides: BufferGel and PRO 2000 Gel

Tabet, Stephen R., Callahan, Marianne M., Mauck, Christine K., Gai, Fang, Coletti, Anne S., Profy, Albert T., Moench, Thomas R., Soto-Torres, Lydia E., Poindexter, Alfred N., Frezieres, Ron G., Walsh,

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2003

File:

PDF, 5.20 MB

2003

26

Rationale and Design for a Multicenter, randomized, double-blind, placebo-controlled, phase 2 study evaluating the safety and efficacy of the soluble Guanylate Cyclase stimulator Praliciguat over 12 weeks in patients with heart failure with preserved ejection fraction (CAPACITY HFpEF)

Udelson, James E., Lewis, Gregory D., Shah, Sanjiv J., Zile, Michael R., Redfield, Margaret M., Burnett, John, Mittleman, Robert S., Profy, Albert T., Seferovic, Jelena P., Reasner, David, Konstam, Ma

Journal:

American Heart Journal

Year:

2020

File:

PDF, 741 KB

2020

27

Crystallization, sequence, and preliminary crystallographic data for an antipeptide Fab 50.1 and peptide complexes with the principal neutralizing determinant of HIV-1 gpl20

Enrico A. Sturam, Robyn L. Stanfield, Gail G. Fieser, Sandra Silver, Michael Roguska, L. Marina Hincapie, Heather K. B. Simmerman, Albert T. Profy, Ian A. Wilson

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1992

Language:

english

File:

PDF, 1000 KB

english, 1992

28

The Differential Binding and Activity of PRO 2000 Against Diverse HIV-1 Envelopes

Sachdev, Darpun D, Zerhouni-Layachi, Bouchra, Ortigoza, Mila, Profy, Albert T, Tuen, Michael, Hioe, Catarina E, Klotman, Mary E

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2009

Language:

english

File:

PDF, 183 KB

english, 2009

29

Safety and Efficacy of the Soluble Guanylate Cyclase Stimulator Praliciguat in Patients with Heart Failure with Preserved Ejection Fraction (Capacity HFpEF): A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial

Udelson, James E., Lewis, Gregory D., Shah, Sanjiv J., Zile, Michael R., Redfield, Margaret M., Burnett, John, Parker, John D., Seferovic, Jelena, Wilson, Phebe J., Mittleman, Robert S., Profy, Albert

Journal:

Journal of Cardiac Failure

Year:

2020

File:

PDF, 181 KB

2020

30

Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop

Robyn L Stanfield, Jayant B Ghiara, Erica Ollmann Saphire, Albert T Profy, Ian A Wilson

Journal:

Year:

2003

Language:

english

File:

PDF, 872 KB

english, 2003

31

Documenting Intermenstrual Bleeding in a Vaginal Microbicide Study: Case Reports and Lessons Learned

Joshi, Smita, Dutta, Soma, Bell, Beverly, Profy, Albert, Kuruc, JoAnn, Fang, Gai, Cianciola, Missy, Maslankowski, Lisa, Soto-Torres, Lydia, Panchanadikar, Anjali, Mehendale, Sanjay, Reynolds, Steven J

Journal:

AIDS Research and Human Retroviruses

Year:

2006

Language:

english

File:

PDF, 548 KB

english, 2006

32

Human Monoclonal Antibody that Recognizes the V3 Region of Human Immunodeficiency Virus gp120 and Neutralizes the Human T-Lymphotropic Virus Type IIIMNStrain

Charles F. Scott, Jr., Sandra Silver, Albert T. Profy, Scott D. Putney, Alphonse Langlois, Kent Weinhold and James E. Robinson

Journal:

Proceedings of the National Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 1.26 MB

english, 1990

33

Safety and tolerability of vaginal PRO 2000 gel in sexually active HIV-uninfected and abstinent HIV-infected women

Mayer, Kenneth H, Karim, Salim Abdool, Kelly, Clifton, Maslankowski, Lisa, Rees, Helen, Profy, Albert T, Day, Jennifer, Welch, Julie, Rosenberg, Zeda

Journal:

Year:

2003

Language:

english

File:

PDF, 119 KB

english, 2003

34

Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells

Liu, Guang, Shea, Courtney M, Jones, Juli E, Price, Gavrielle M, Warren, William, Lonie, Elisabeth, Yan, Shu, Currie, Mark G, Profy, Albert T, Masferrer, Jaime L., Zimmer, Daniel Paul

Journal:

American journal of physiology. Renal physiology

Year:

2020

File:

PDF, 1.91 MB

2020

35

Direct measurement of in-vivo vaginal microbicide levels of PRO 2000 achieved in a human safety study

Lacey, Charles JN, Wright, Anne, Weber, Jonathan N, Profy, Albert T

Journal:

Year:

2006

Language:

english

File:

PDF, 106 KB

english, 2006

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